You must be carefull at this :
Excessive volume of emails (exceeding host's per-minute, per-hour, per-day caps). You need to find out from your host what the limits are (important for newsletter).
Newsletters and other "not necessary" communications (mass mailings) have to be explicitly "opt in", to avoid legal problems and accusations of spamming.
Respect the regulation and if the customer has opt in the newsletter.
If your host (or other systems, such as Yahoo or Gmail) are flagging the content of any of your emails as spam, you will need to adjust the wording and contents to pass the spam tests.